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. 2000 Apr 1;105(7):863–873. doi: 10.1172/JCI8256

Figure 7.

Figure 7

Ontogeny of ectopic UV orifice in Bmp4+/– embryos. (a and b) At E13.5, the ureter is connected to the cloaca in the wild type (a), whereas the ureter of the mutant is still connected to WD (b). (c and d) At E12.5, the ureter still drains to WD in both the wild type (c) and the mutant (d). The length of the CMD is abnormally long in the mutant. e and f are adjacent sections to c and d, respectively, and subjected to TUNEL staining. Apoptosis of CMD is comparable between the wild type (e) and mutant (f). (g and h) c-ret and Wnt 11 whole-mount in situ hybridization for wild-type (g) (n = 4) and mutant (h) (n = 3) E11.0 embryos. The position of the budding from WD is indicated by arrows, and the 24th, 25th, and 26th somite pairs are marked by arrowheads. The position of the budding in the wild type corresponds to the approximately 26th somite (g), whereas that in the mutant corresponds to the approximately 25th somite (h). The dashed lines in g and h show the approximate plane of the sections for a–f. Ut, ureter; WD, Wolffian duct; CMD, common mesonephric duct; Cl, cloaca; UB, ureteric bud.L, left; R, right. Bar, 100 μm (a–f); 300 μm (g and h).