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. 2013 Sep 16;8(9):e73820. doi: 10.1371/journal.pone.0073820

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© 2013 Cressman et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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At subthreshold ( mM) it is possible to elicit bursts using large current injections. In this figure, all stimuli are ms, . The model neuron cannot burst more quickly than a certain intrinsic frequency, even if the stimulation is applied more frequently. Panel (A) shows the potassium ion concentration over 20 minutes as the stimulation frequency is increased. Every 4 minutes the frequency is increased by a factor of , starting at 0.0316 Hz when . The evolution of the system at each individual frequency is shown in phase planes (B–F), which correspond to the identically labeled epochs of the voltage time trace above.

Inline graphic — At subthreshold ( mM) it is possible to elicit bursts using large current injections. In this figure, all stimuli are ms, . The model neuron cannot burst more quickly than a certain intrinsic frequency, even if the stimulation is applied more frequently. Panel (A) shows the potassium ion concentration over 20 minutes as the stimulation frequency is increased. Every 4 minutes the frequency is increased by a factor of , starting at 0.0316 Hz when . The evolution of the system at each individual frequency is shown in phase planes (B–F), which correspond to the identically labeled epochs of the voltage time trace above.