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. 2013 Sep 16;8(9):e74049. doi: 10.1371/journal.pone.0074049

Figure 1. Phenotype characterization of E12.5 Lmx1a-dr/dr mice.

Figure 1

(A–E′) Sagittal expression analysis of Lmx1a transcript in medial to lateral brain sections. Laterally, Lmx1a expression is clearly down-regulated in the Dreher homozygous mutant (D′,E′, arrowheads). (F–J′) Th transcript is rostral-laterally decreased (arrowheads), but also medially. (K–O′) Pitx3 and (P–T′) En1 display a subtle decreased expression in Lmx1a-dr/dr tissue. (U–Y′) Aadc expression is expanded rostrally in the absence of Lmx1a (arrowheads). (AA–EE′′) Pseudo-overlays of wild-type Lmx1a (red; generated from A–E) and Th (green; generated from F–J) transcript expression, showing complete overlap in medial sections and only partial overlap in lateral sections (white arrowheads).