Table 2. Results from meta-analysis of −607 C>A and cancer risk.
AA vs. CC | CA vs. CC | CA/AA vs. CC | AA vs. CC/CA | |||||||
N | OR | Ph | OR | Ph | OR | Ph | OR | Ph | ||
Total | 23 | 1.11(0.92, 1.33) | 0.013 | 1.19(1.04, 1.37)* | 0.033 | 1.17(1.01, 1.34)* | 0.007 | 0.99(0.85, 1.15) | 0.032 | |
Cancer Types | ||||||||||
GC | 4 | 1.41(0.36, 5.45) | <0.001 | 1.45(0.97, 2.18) | 0.525 | 1.41(0.67, 2.95) | 0.018 | 1.12(0.33, 3.81) | <0.001 | |
NC | 4 | 1.31(0.96, 1.77) | 0.759 | 1.33(1.03, 1.72)* | 0.704 | 1.32(1.04, 1.69)* | 0.823 | 1.08(0.84, 1.39) | 0.547 | |
GUC | 4 | 0.87(0.67, 1.12) | 0.363 | 0.86(0.63, 1.16) | 0.068 | 0.85(0.64, 1.13) | 0.076 | 0.94(0.77, 1.15) | 0.914 | |
GIC | 6 | 1.12(0.88, 1.42) | 0.648 | 1.32(1.08, 1.63)* | 0.327 | 1.25(1.05, 1.50)* | 0.458 | 0.95(0.78, 1.17) | 0.681 | |
BC | 2 | 1.33(0.80, 2.22) | 0.438 | 1.17(0.81, 1.68) | 0.532 | 1.20(0.85, 1.70) | 0.784 | 1.23(0.72, 2.10) | 0.274 | |
Others | 3 | 1.26(0.61, 2.62) | 0.080 | 1.43(0.85, 2.42) | 0.100 | 1.37(0.79, 2.39) | 0.055 | 0.98(0.62, 1.56) | 0.277 | |
Ethnicities | ||||||||||
Asian | 17 | 1.15(0.90, 1.46) | 0.003 | 1.15(0.98, 1.34) | 0.099 | 1.15(0.97, 1.37) | 0.010 | 1.04(0.85, 1.25) | 0.011 | |
Caucasian | 5 | 1.02(0.78, 1.34) | 0.473 | 1.29(0.91, 1.85) | 0.041 | 1.20(0.89, 1.62) | 0.083 | 0.89(0.70, 1.14) | 0.620 | |
African | 1 | 1.06(0.56, 2.03) | N/A | 1.58(0.95, 2.62) | N/A | 1.42(0.88, 2.30) | N/A | 0.79(0.46, 1.38) | N/A | |
Source of Controls | ||||||||||
PB | 14 | 1.01(0.83, 1.23) | 0.196 | 1.18(1.01, 1.37)* | 0.189 | 1.12(0.97, 1.29) | 0.190 | 0.91(0.76, 1.09) | 0.154 | |
HB | 9 | 1.33(0.92, 1.91) | 0.009 | 1.25(0.94, 1.65) | 0.018 | 1.30(0.96, 1.75) | 0.002 | 1.14(0.87, 1.48) | 0.044 | |
Sample Size | ||||||||||
Largea | 4 | 1.05(0.77, 1.42) | 0.192 | 1.05(0.78, 1.42) | 0.080 | 1.05(0.78, 1.41) | 0.063 | 1.01(0.83, 1.22) | 0.750 | |
Smallb | 19 | 1.14(0.91, 1.42) | 0.011 | 1.24(1.06, 1.45)* | 0.086 | 1.21(1.03, 1.42)* | 0.019 | 0.99(0.82, 1.21) | 0.011 |
GC: Gynecological cancer; NC: Nasopharyngeal carcinoma; GUC: Genitourinary system cancer; GIC: Gastrointestinal cancer; BC: Breast cancer; N: number of studies included; OR: odds ratio; Ph: p value for heterogeneity;
OR with statistical significance; a: studies with more than 500 participants; b: studies with less than 500 participants;