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. 2013 Sep 16;8(9):e73671. doi: 10.1371/journal.pone.0073671

Table 2. Results from meta-analysis of −607 C>A and cancer risk.

AA vs. CC CA vs. CC CA/AA vs. CC AA vs. CC/CA
N OR Ph OR Ph OR Ph OR Ph
Total 23 1.11(0.92, 1.33) 0.013 1.19(1.04, 1.37)* 0.033 1.17(1.01, 1.34)* 0.007 0.99(0.85, 1.15) 0.032
Cancer Types
GC 4 1.41(0.36, 5.45) <0.001 1.45(0.97, 2.18) 0.525 1.41(0.67, 2.95) 0.018 1.12(0.33, 3.81) <0.001
NC 4 1.31(0.96, 1.77) 0.759 1.33(1.03, 1.72)* 0.704 1.32(1.04, 1.69)* 0.823 1.08(0.84, 1.39) 0.547
GUC 4 0.87(0.67, 1.12) 0.363 0.86(0.63, 1.16) 0.068 0.85(0.64, 1.13) 0.076 0.94(0.77, 1.15) 0.914
GIC 6 1.12(0.88, 1.42) 0.648 1.32(1.08, 1.63)* 0.327 1.25(1.05, 1.50)* 0.458 0.95(0.78, 1.17) 0.681
BC 2 1.33(0.80, 2.22) 0.438 1.17(0.81, 1.68) 0.532 1.20(0.85, 1.70) 0.784 1.23(0.72, 2.10) 0.274
Others 3 1.26(0.61, 2.62) 0.080 1.43(0.85, 2.42) 0.100 1.37(0.79, 2.39) 0.055 0.98(0.62, 1.56) 0.277
Ethnicities
Asian 17 1.15(0.90, 1.46) 0.003 1.15(0.98, 1.34) 0.099 1.15(0.97, 1.37) 0.010 1.04(0.85, 1.25) 0.011
Caucasian 5 1.02(0.78, 1.34) 0.473 1.29(0.91, 1.85) 0.041 1.20(0.89, 1.62) 0.083 0.89(0.70, 1.14) 0.620
African 1 1.06(0.56, 2.03) N/A 1.58(0.95, 2.62) N/A 1.42(0.88, 2.30) N/A 0.79(0.46, 1.38) N/A
Source of Controls
PB 14 1.01(0.83, 1.23) 0.196 1.18(1.01, 1.37)* 0.189 1.12(0.97, 1.29) 0.190 0.91(0.76, 1.09) 0.154
HB 9 1.33(0.92, 1.91) 0.009 1.25(0.94, 1.65) 0.018 1.30(0.96, 1.75) 0.002 1.14(0.87, 1.48) 0.044
Sample Size
Largea 4 1.05(0.77, 1.42) 0.192 1.05(0.78, 1.42) 0.080 1.05(0.78, 1.41) 0.063 1.01(0.83, 1.22) 0.750
Smallb 19 1.14(0.91, 1.42) 0.011 1.24(1.06, 1.45)* 0.086 1.21(1.03, 1.42)* 0.019 0.99(0.82, 1.21) 0.011

GC: Gynecological cancer; NC: Nasopharyngeal carcinoma; GUC: Genitourinary system cancer; GIC: Gastrointestinal cancer; BC: Breast cancer; N: number of studies included; OR: odds ratio; Ph: p value for heterogeneity;

*

OR with statistical significance; a: studies with more than 500 participants; b: studies with less than 500 participants;