Table 3. Results from meta-analysis of −137 G>C and cancer risk.
CC vs. GG | GC vs. GG | GC/CC vs. GG | CC vs. GG/GC | |||||||
N | OR | Ph | OR | Ph | OR | Ph | OR | Ph | ||
Total | 21 | 1.09(0.78, 1.51) | <0.001 | 1.15(0.94, 1.40) | <0.001 | 1.13(0.92, 1.39) | <0.001 | 1.02(0.76, 1.37) | 0.005 | |
Cancer Types | ||||||||||
GC | 4 | 0.80(0.44, 1.47) | 0.301 | 1.17(0.73, 1.87) | 0.032 | 1.11(0.72, 1.73) | 0.037 | 0.75(0.41, 1.38) | 0.274 | |
NC | 4 | 2.10(1.34, 3.29)* | 0.538 | 1.48(1.18, 1.86)* | 0.512 | 1.57(1.26, 1.96)* | 0.373 | 1.82(1.17, 2.84)* | 0.611 | |
GUC | 4 | 1.10(0.45, 2.72) | 0.065 | 1.20(0.72, 2.00) | <0.001 | 1.19(0.70, 2.04) | <0.001 | 1.04(0.52, 2.09) | 0.197 | |
GIC | 5 | 0.96(0.41, 2.23) | 0.001 | 1.24(0.87, 1.76) | 0.007 | 1.18(0.78, 1.80) | <0.001 | 0.90(0.43, 1.88) | 0.005 | |
Others | 4 | 0.73(0.44, 1.21) | 0.310 | 0.68(0.30, 1.51) | <0.001 | 0.71(0.37, 1.36) | <0.001 | 0.80(0.45, 1.41) | 0.197 | |
Ethnicities | ||||||||||
Asian | 15 | 1.13(0.72, 1.78) | <0.001 | 1.35(1.12, 1.64)* | 0.001 | 1.31(1.05, 1.64)* | <0.001 | 1.00(0.66, 1.51) | 0.001 | |
Caucasian | 4 | 0.91(0.55, 1.51) | 0.296 | 0.64(0.33, 1.23) | <0.001 | 0.70(0.39, 1.24) | <0.001 | 0.99(0.63, 1.54) | 0.360 | |
African | 1 | 1.28(0.57, 2.86) | N/A | 1.19(0.75, 1.87) | N/A | 1.20(0.78, 1.86) | N/A | 1.18(0.54, 2.56) | N/A | |
Mixed | 1 | 0.85(0.31, 2.35) | N/A | 0.74(0.48, 1.15) | N/A | 0.75(0.49, 1.14) | N/A | 0.93(0.34, 2.56) | N/A | |
Source of Controls | ||||||||||
PB | 12 | 0.85(0.55, 1.33) | 0.005 | 0.90(0.70, 1.15) | <0.001 | 0.88(0.69, 1.13) | <0.001 | 0.87(0.58, 1.31) | 0.013 | |
HB | 9 | 1.49(0.97, 2.27) | 0.078 | 1.62(1.34, 1.96)* | 0.131 | 1.59(1.29, 1.97)* | 0.033 | 1.26(0.85, 1.86) | 0.129 | |
Sample Size | ||||||||||
Large a | 4 | 1.30(0.51, 3.27) | 0.019 | 1.14(0.73, 1.80) | <0.001 | 1.16(0.70, 1.92) | <0.001 | 1.27(0.60, 2.70) | 0.073 | |
Small b | 17 | 1.03(0.73, 1.46) | 0.003 | 1.14(0.91, 1.45) | <0.001 | 1.12(0.89, 1.42) | <0.001 | 0.97(0.70, 1.33) | 0.016 |
GC: Gynecological cancer; NC: Nasopharyngeal carcinoma; GUC: Genitourinary system cancer; GIC: Gastrointestinal cancer; N: number of studies included; OR: odds ratio; Ph: p value for heterogeneity;
OR with statistical significance;
studies with more than 500 participants;
studies with less than 500 participants;