Figure 1.
Map of the Sle2c1 locus. A, Location of Sle2c1 relative to Sle2 on chromosome 4. The NZB/NZW derivation of the region is shown, as well as the markers that define the Sle2 and Sle2c1 termini. B, Sle2c1 and its three recombinants define the critical interval (double-arrowed line) associated with Pc B1a cell expansion. The location of Cdkn2c and that of the markers defining the termini of each recombinant are indicated on the top. NZM2410 (NZW or NZB)-derived intervals are indicated by solid boxes, with the area of recombination between the NZM2410 and B6 genomes indicated by the lines on each side. Intervals associated with an expanded Pc B1a cell phenotype are shown in black, while the Sle2c1.Rec1b interval associated with a B6-like B1a phenotype is indicated in grey.