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The −74 C/T promoter SNP regulates Cdkn2c transcription. Luciferase assays in NIH3T3 (A-B) and Raji (C) cells transfected with three Cdkn2c promoter-luciferase constructs with serial 5′ deletions. In B, an E2F1 expression vector was co-transfected with the Cdkn2c promoter constructs. Data was expressed as the relative induction of luciferase activity induced by each promoter construct over empty vector. *: p < 0.05, **: p < 0.01, and ***: p < 0.001.
