Figure 4.

Cross-reactivity of GA-reactive T-cell lines is increased after daily injections of GA. Percentages of the GA-induced T-cell lines cross-reacting to each APL tested at each time point are shown for the 7 patients encoded by gray scale. Proliferative IFN-γ and IL-5 responses were examined for all T-cell lines and are represented separately in the top, middle, and lower third. A minimum SI of 2 and a difference of 2 SD over the background was required for classification as a cross-reactive T-cell line.