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Analysis of an E14.5dpc FVII–/–/PC–/– embryo. (a) Gross appearance of an embryo. The hemorrhagic phenotype observed at E17.5dpc is readily occurring at E14.5dpc. Bleeding can be observed along the spinal column, in the brain, and in peripheral regions such as the snout. (b–e) Histological analyses of whole sectioned embryos. Hemorrhage (b) and fibrin deposition (c) are seen in the snout, plus bleeding in the lateral ventricle (d) and behind the spinal column (e).
