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Mithramycin A regulates the mTOR/Mcl-1/truncated Bid signaling pathway. (A) Levels of phospho-mTOR (p-mTOR), total mTOR, Mcl-1 and truncated Bid (tBid) extracted from athymic nude mice xenografts bearing DU145 cells were determined by Western blot analysis. (B) Working model by which the treatment of Mithramycin A (Mith) induces apoptosis in human prostate cancer through the mTOR/Mcl-1/tBid signaling pathway.
