Table 3.

Maternal plasma levels of vitamins and metabolic markers in pregnancy week 18 according to folic acid user status

Parameters, median (interquartile range)	Folic acid user	Folic acid non-usera	P valuesb
Number	N=2067	N=844
Serum Folate, nmol/L	10.6 (7.4–17.7)	5.6 (4.3–7.7)	<0.001
Serum Cobalamin, pmol/L	309 (249–378)	291 (233–366)	<0.001
Plasma PLP, nmol/L	29.3 (21.9–42.0)	24.1 (18.6–30.4)	<0.001
Plasma Riboflavin, nmol/L	8.4 (5.7–14.1)	6.9 (4.8–10.9)	<0.001
Plasma tHcy, μmol/L	4.75 (4.14–5.54)	5.53 (4.77–6.58)	<0.001
Plasma MMA, μmol/L	0.13 (0.10–0.16)	0.13 (0.11–0.16)	0.11
Plasma 3-OH-kynurenine, μmol/L	23.6 (18.0–30.0)	24.3 (18.9–31.8)	0.005

^aNo supplements, n=582, + Other supplements, n=262

^bMann Whitney test