Table 4.
Maternal plasma levels of vitamins and metabolic markers in pregnancy week 18 according to the degree of folic acid supplement use
| Parameters, median (interquartile range) | Folic acid use every week from week −4 to +17 | Folic acid use sometimes from week −4 to +17 | Folic acid non usera | P valuesb |
|---|---|---|---|---|
| Number | N=238 | N=1829 | N=844 | |
| Serum Folate, nmol/L | 15.7 (9.4–23.1) | 10.2 (7.3–16.6) | 5.7 (4.3–7.7) | <0.001 |
| Serum Cobalamin, pmol/L | 319 (260–395) | 307 (248–375) | 291 (233–366) | <0.001 |
| Plasma PLP, nmol/L | 36.9 (25.5–53.4) | 28.3 (21.6–40.6) | 24.1 (18.6–30.4) | <0.001 |
| Plasma Riboflavin, nmol/L | 10.2 (6.9–16.6) | 8.2 (5.6–13.7) | 6.9 (4.8–10.9) | <0.001 |
| Plasma tHcy, μmol/L | 4.42 (3.99–5.08) | 4.79 (4.21–5.56) | 5.51 (4.76–6.52) | <0.001 |
| Plasma MMA, μmol/L | 0.12 (0.10–0.16) | 0.13 (0.10–0.16) | 0.13 (0.11–0.16) | 0.20 |
| Plasma 3-OH-kynurenine, μmol/L | 22.3 (17.0–28.1) | 23.7 (18.1–30.3) | 24.2 (18.9–31.8) | 0.001 |
a
No supplements, n=584 + other supplements, n=263
b
Kruskal Wallis test