Table 5.
Maternal plasma levels of vitamins and metabolic markers in pregnancy week 18 according to maternal use of folic acid and other micronutrients
| Parameters, median (interquartile range) | Folic acid only user | Folic acid and other supplements user | Other supplement only user | No supplements user | P valuesa |
|---|---|---|---|---|---|
| Number | N=406 | N=1661 | N=262 | N=582 | |
| Serum Folate, nmol/L | 8.8 (6.6–13.5) | 11.2 (7.7–18.7) | 5.6 (4.3–7.3) | 5.8 (4.2–7.7) | <0.001 |
| Serum Cobalamin, pmol/L | 289 (240–358) | 313 (251–382) | 294 (234–368) | 287 (233–364) | <0.001 |
| Plasma PLP, nmol/L | 24.7 (19.4–31.0) | 31.3 (22.8–44.8) | 25.6 (19.4–34.3) | 23.6 (18.3–29.5) | <0.001 |
| Plasma Riboflavin, nmol/L | 6.9 (5.1–10.5) | 8.8 (5.9–14.8) | 7.3 (5.0–11.3) | 6.8 (4.8–10.8) | <0.001 |
| Plasma tHcy, μmol/L | 4.87 (4.31–5.64) | 4.70 (4.11–5.49) | 5.51 (4.77–6.50) | 5.53 (4.75–6.57) | <0.001 |
| Plasma MMA, μmol/L | 0.13 (0.10–0.16) | 0.13 (0.10–0.16) | 0.13 (0.11–0.17) | 0.13 (0.10–0.16) | 0.15 |
| Plasma 3-OH-Kynurenine, μmol/L | 23.9 (18.7–30.5) | 23.5 (17.8–29.9) | 23.7 (18.7–31.2) | 24.6 (19.0–32.0) | 0.02 |
a
Kruskal Wallis test