Table 3.
Genotype and allele frequencies of the five investigated TAP gene polymorphisms in women with cervical intraepithelial neoplasia (CIN) and controls.
| Gene polymorphisms | Controls (%) | CIN (%) | P a | OR (95% CI) |
|---|---|---|---|---|
| TAP 1341 | 0.08 | 1.4 (1.0-2.0) | ||
| wt/wt | 155 (75.2%) | 423 (68.7%) | ||
| wt/mt | 44 (21.4%) | 172 (27.9%) | ||
| mt/mt | 7 (3.4%) | 21 (3.4%) | ||
| TAP 2254 | 0.3 | 1.3 (0.9–1.8) | ||
| wt/wt | 161 (78.2%) | 455 (73.9%) | ||
| wt/mt | 39 (18.9%) | 148 (24.0%) | ||
| mt/mt | 6 (2.9%) | 12 (1.9%) | ||
| TAP 1135 | 0.8 | 0.9 (0.7–1.3) | ||
| wt/wt | 143 (69.4%) | 435 (70.6%) | ||
| wt/mt | 51 (24.8%) | 165 (26.8%) | ||
| mt/mt | 12 (5.8%) | 16 (2.6%) | ||
| TAP 1693 | 0.3 | 1.3 (0.8–2.2) | ||
| wt/wt | 184 (89.3%) | 531 (86.2%) | ||
| wt/mt | 22 (10.7%) | 84 (13.6%) | ||
| mt/mt | 0 (0%) | 1 (0.2%) | ||
| TAP 1993 | 0.2 | 0.8 (0.6–1.1) | ||
| wt/wt | 90 (43.7%) | 301 (48.9%) | ||
| wt/mt | 92 (44.7%) | 248 (40.3%) | ||
| mt/mt | 24 (11.7%) | 66 (10.7%) |
aStatistical analysis by chi-square test are calculated wt/wt versus wt/mt and mt/mt.
TAP: transporter associated with antigen processing.
CIN: cervical intraepithelial neoplasia.
OR (95% CI): odds ratio (95% confidence interval).