Table 1.
Demographic data, lipid status parameters, inflammatory markers and SDMA concentrations in CKD and RT patients with impaired and nonimpaired FMD.
| CKD patients FMD | RT patients FMD | |||||
|---|---|---|---|---|---|---|
| Non-impaired (n = 44) |
Impaired (n = 20) |
P | Non-impaired (n = 36) |
Impaired (n = 16) |
P | |
| Age, years | 38.4 ± 12.7 | 44.2 ± 12.0 | 0.238 | 39.5 ± 8.8 | 39.0 ± 8.6 | 0.894 |
|
| ||||||
| Male, % | 45.5 | 40.0 | 0.773 | 61.1 | 62.5 | 0.946 |
|
| ||||||
| BMI, kg/m2 | 23.63 ± 3.40 | 23.09 ± 10.44 | 0.875 | 25.48 ± 4.30 | 25.18 ± 3.11 | 0.856 |
|
| ||||||
| CKD duration, months* | 20.27 (10.59–38.80) |
88.80 (25.85–151.74) |
0.076 | 140.44 (103.08–177.81) |
145.63 (92.79–198.45) |
0.811 |
|
| ||||||
| Creatinine, μmol/L* | 233.94 (189.45–288.88) |
412.80 (202.65–622.94) |
0.164 | 165.99 (138.46–198.99) |
222.13 (141.40–302.85) |
0.202 |
|
| ||||||
| GFR, mL/min/1.73 m2 | 27.98 ± 13.48 | 19.54 ± 11.78 | 0.104 | 40.97 ± 13.86 | 32.95 ± 13.48 | 0.182 |
|
| ||||||
| Albumin, g/L | 40.18 ± 5.93 | 37.40 ± 7.07 | 0.256 | 43.47 ± 3.24 | 40.57 ± 2.70 | 0.049 |
|
| ||||||
| Uric acid, μmol/L | 475.45 ± 88.20 | 403.40 ± 79.88 | 0.035 | 408.39 ± 71.39 | 382.38 ± 89.62 | 0.435 |
|
| ||||||
| Urea, mmol/L* | 15.20 (12.56–17.85) |
19.20 (13.44–24.95) |
0.157 | 10.47 (8.36–13.12) |
14.02 (9.30–18.74) |
0.229 |
|
| ||||||
| Cholesterol, mmol/L | 5.51 ± 1.20 | 5.25 ± 1.53 | 0.596 | 5.63 ± 0.97 | 6.49 ± 1.19 | 0.064 |
|
| ||||||
| LDL-cholesterol, mmol/L | 3.38 ± 0.99 | 3.46 ± 1.36 | 0.859 | 3.41 ± 0.64 | 4.25 ± 1.02 | 0.019 |
|
| ||||||
| HDL-cholesterol, mmol/L | 1.22 ± 0.22 | 1.06 ± 0.18 | 0.045 | 1.28 ± 0.39 | 1.30 ± 0.31 | 0.904 |
|
| ||||||
| Triglyceride, mmol/L* | 1.58 (1.25–2.00) |
1.73 (1.16–2.58) |
0.653 | 1.78 (1.47–2.17) |
2.05 (1.75–2.40) |
0.232 |
|
| ||||||
| Fibrinogen*, g/L | 4.51 (4.02–5.06) |
5.38 (4.03–7.21) |
0.166 | 4.58 (3.94–5.31) |
4.65 (3.55–6.08) |
0.909 |
|
| ||||||
| hs-CRP*, mg/L | 0.45 (0.28–0.73) |
5.96 (1.02–34.91) |
0.010 | 1.53 (0.74–3.17) |
1.79 (0.87–3.71) |
0.772 |
|
| ||||||
| IL-6*, pg/mL | 1.93 (1.44–2.60) |
4.58 (3.21–6.53) |
<0.001 | 4.29 (2.96–6.19) |
3.97 (2.64–5.97) |
0.802 |
|
| ||||||
| SAA*, mg/L | 2.18 (1.92–2.47) |
3.78 (2.06–6.97) |
0.006 | 9.86 (5.96–16.37) |
8.88 (3.71–21.28) |
0.809 |
|
| ||||||
| NT-proBNP*, ng/L | 232.27 (79.43–679.20) |
645.65 (245.47–1258.1) |
0.104 | 199.99 (91.83–435.51) |
348.34 (183.65–660.69) |
0.353 |
|
| ||||||
| SDMA*, μmol/L | 1.34 (1.19–1.51) |
1.97 (1.69–2.28) |
<0.001 | 1.25 (1.10–1.42) |
1.30 (0.90–1.89) |
0.759 |
|
| ||||||
| O2∙−, μmol/min L | 49.77 (34.83–71.29) |
28.84 (9.86–84.14) |
0.154 | 46.56 (33.73–64.27) |
44.67 (35.73–55.85) |
0.860 |
Continuous variables are presented as mean ± standard deviation and compared by Student's t-test, whereas categorical variables are presented as relative frequencies and compared by Chi-square test.
*Values for CKD duration, creatinine, urea, TG, fibrinogen, hs-CRP, IL-6, SAA, NT-proBNP, SDMA, and O2∙− are presented as geometrical mean and 95% confidence intervals (CIs). Logarithmic transformation of the values was performed before the analysis.