Table 1.
The relationship of FXYD-3 protein expression with clinicopathological and biological variables in the patients with ESCC.
| Variables | N | FXYD-3 expression | χ 2 | P value | |
|---|---|---|---|---|---|
| Negative (%) | Positive (%) | ||||
| Gender | |||||
| Male | 50 | 20 (40) | 30 (60) | 0.037 | 0.847 |
| Female | 14 | 6 (43) | 8 (57) | ||
| Age (years) | |||||
| ≤50 | 19 | 8 (42) | 11 (58) | 0.025 | 0.876 |
| >50 | 45 | 18 (40) | 27 (60) | ||
| Tumour location | |||||
| Upper | 7 | 3 (43) | 4 (57) | 2.556 | 0.279 |
| Middle | 36 | 14 (39) | 22 (61) | ||
| Lower | 21 | 9 (43) | 12 (57) | ||
| Tumour size (cm) | |||||
| ≤3 | 26 | 10 (38) | 16 (62) | 0.085 | 0.771 |
| >3 | 38 | 16 (42) | 22 (58) | ||
| Lymph node status | |||||
| Nonmetastasis | 44 | 21 (48) | 23 (52) | 2.944 | 0.086 |
| Metastasis | 20 | 5 (25) | 15 (75) | ||
| Grade of differentiation | |||||
| I | 20 | 11 (55) | 9 (45) | 2.556 | 0.279 |
| II | 39 | 13 (33) | 26 (67) | ||
| III | 5 | 2 (40) | 3 (60) | ||
| Depth of invasion | |||||
| Mucosa and submucosa | 14 | 9 (64) | 5 (36) | 4.159 | 0.041 |
| Muscularis and adventitia | 50 | 17 (34) | 33 (66) | ||
| TNM stage | |||||
| I | 14 | 10 (71) | 4 (29) | 7.049 | 0.008 |
| II + III + IV | 50 | 16 (32) | 34 (68) | ||
| Survival (years) | |||||
| ≥5 | 11 | 8 (73) | 3 (27) | 2.508 | 0.113 |
| <5 | 27 | 12 (44) | 15 (56) | ||
| PINCH | |||||
| Negative | 28 | 15 (54) | 13 (46) | 3.459 | 0.063 |
| Positive | 36 | 11 (31) | 25 (69) | ||
ESCC: esophageal squamous cell carcinoma.
PINCH: particularly interesting new cysteine-histidine rich protein.