Table 1.
Macrophage cytokine levels in unstimulated and LPS stimulated culture conditions.
| Cytokines pg/ml | Unstimulated: Median (IQR) | LPS: Median (IQR) | ||||
|---|---|---|---|---|---|---|
| C57 | BTBR | p-value | C57 | BTBR | p-value | |
| IL-1β | 3.9 (14.39) | BLD | N/A | BLD | 16.56 (38.26) | 0.351 |
| IL-6 | 0.23 (2.22) | BLD | N/A | 1254 (760.2) | 3112 (1189) | 0.0003* |
| IL-10 | BLD | BLD | N/A | 448.4 (307.6) | 284.2 (195.2) | 0.023* |
| IL-12p40 | 15.3 (7.56) | 20.58 (7.56) | 0.049* | 446.4 (322.5) | 2779 (1652) | 0.0002* |
| IL-12p70 | BLD | BLD | N/A | BLD | 56.81 (56.81) | N/A |
| IP-10 | 65.45 (30.94) | 70.17 (93.81) | 0.142 | 8875 (2859) | 14535 (1294) | 0.0007* |
| MCP-1 | BLD | 15.63 (32.74) | N/A | 750.4 (442.6) | 3117 (1036) | 0.0002* |
| TNF-α | BLD | 0.13 (5.1) | N/A | 448.3 (407.5) | 595.2 (217.2) | 0.408 |
| MIP-1α | 39.27 (22.41) | BLD | N/A | 1945 (713) | 4342 (2828) | 0.0002* |
| MIP-1β | 63.35 (36.58) | 56.76 (83.06) | 0.671 | 10214 (2530) | 23060 (9262) | 0.0003* |
Median cytokine measurements and interquartile ranges (IQR) in pg/ml. All p-values were calculated by two-tailed Mann Whitney U-test.
*
Significant p-values; BLD: Below level of detection; N/A: Not applicable, p-values could not be calculated.