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Increased SOD activity in zebrafish maintained in EUK139. Zebrafish were maintained free swimming in concentrations of EUK139 ranging from 0 to 200 μM for 1 hr, at which time the fish were sacrificed and then frozen in liquid nitrogen. The fish were thawed and the tail was removed, homogenized and the MnSOD biochemical activity determined. Fish maintained in 100 μM drug had a significantly increased MnSOD biochemical activity compared to control untreated fish (p=0.0178).
