Table V.

Analysis of hematopoiesis in long term cultures of caspase-1 –/– mouse bone marrow cells: weekly production of day 14 colony-forming progenitor cells.

	Week 1	Week 2	Week 3	Week 4	Week 5
Caspase 1 –/–	144.3±7.8 (n=3)	302.7±11.4 (n=3)	346.0±18.0 (n=3)	228.0±14.0 (n=3)	288.3±11.0 (n=3)
Caspase 1 +/+	327.0±19.5 (n=3)	203.3±10.1 (n=3)	123.7±10.4 (n=3)	222.3±13.6 (n=3)	208.0±6.0 (n=3)
p-value	0.0001	0.0003	<0.0001	0.6412	0.0004
	Week 6	Week 7	Week 8	Week 9	Week 10
Caspase 1 –/–	303.7±10.0 (n=3)	153.0±9.0 (n=3)	181.7±7.5 (n=3)	127.7±8.0 (n=3)	257.7±6.5 (n=3)
Caspase 1 +/+	225.7±12.3 (n=3)	107.3±5.0 (n=3)	132.7±7.0 (n=3)	171.0±7.0 (n=3)	176.0±7.5 (n=3)
p-value	0.0011	0.0016	0.0012	0.0021	0.0001
	Week 11	Week 12	Week 13	Week 14	Week 15
Caspase 1 –/–	166.3±5.0 (n=3)	255.0±7.0 (n=3)	200.3±12.3 (n=3)	104.3±11.0 (n=3)	242.0±18.7 (n=3)
Caspase 1 +/+	150.7±13.3 (n=3)	179.7±7.1 (n=3)	46.3±6.5 (n=3)	111.3±11.0 (n=3)	104.3±10.0 (n=3)
p-value	0.1293	0.0002	<0.0001	0.4790	0.0004
	Week 16	Week 17	Week 18	Week 19	Week 20
Caspase 1 –/–	108.0±6.6 (n=3)	167.0±4.6 (n=3)	66.0±6.0 (n=3)	193.7±9.3 (n=3)	169.0±5.0 (n=3)
Caspase 1 +/+	5.0±1.0 (n=3)	ND	ND	ND
p-value	<0.0001
	Week 21	Week 22	Week 23	Week 24	Week 25
Caspase 1 –/–	82.7±8.3 (n=3)	157.7±9.1 (n=3)	118.0±4.6 (n=3)	35.3±5.5 (n=3)	59.3±5.0 (n=3)
	Week 26	Week 27	Week 28	Week 29	Week 30
Caspase 1 –/–	60.7±7.5 (n=3)	75.3±4.5 (n=3)	77.3±5.0 (n=3)	97.0±6.6 (n=3)	73.0±7.5 (n=3)
	Week 31	Week 32	Week 33	Week 34	Week 35
Caspase 1 –/–	22.3±2.5 (n=3)	18.7±5.0 (n=3)	14.3±3.2 (n=3)	8.7±2.3 (n=3)	60.0±10.0 (n=3)
	Week 36	Week 37	Week 38	Week 39	Week 40
Caspase 1 –/–	114.7±7.0 (n=3)	111.7±8.0 (n=3)

Data are summarized as mean±standard deviation, n is the number of observations, and p-values were calculated with the two-sided two sample t-test. Significant p-values are shown in bold. Beginning at week 17 no day 7 colonies in the caspase-1 +/+ LTBMCs were detected (ND).