Table 1.
Frequencies of CYP2C19 alleles and genotypes in the Saudi population sample (n=201)
| CYP2C19 | Allele | Frequency | 95% Confidence interval | Actual number | Expected number by Hardy-Weinberg law |
|---|---|---|---|---|---|
| Alleles | *1 | 0.629 | 0.585 - 0.674 | 253 | N/A |
| *17 | 0.257 | 0.216 - 0.299 | 103 | N/A | |
| *2 | 0.112 | 0.082 - 0.147 | 45 | N/A | |
| *4 | 0.002 | 0.000 - 0.007 | 1 | N/A | |
| Total | 1.00 | 402 | N/A | ||
| Phenotypes | Genotypes | ||||
| EM | *1*1 | 0.403 | 0.338 - 0.468 | 81 (%) | 79.6131a (%) |
| *1*17 | 0.304 | 0.239 - 0.363 | 61 (%) | 64.8233a (%) | |
| *2*17 | 0.07 | 0.04 - 0.104 | 14 (%) | 11.5298a (%) | |
| *4 *17 | 0 (%) | 0.2562a (%) | |||
| Total | 0.776 | 156 | |||
| IM | *1*2 | 0.145 | 0.100 - 0.194 | 29 (%) | 28.3208a (%) |
| *1*4 | 0.004 | 0.00 - 0.015 | 1 (%) | 0.6293a (%) | |
| Total | 0.149 | 30 (%) | |||
| UM | *17*17 | 0.07 | 0.04 - 0.104 | 14 (%) | 13.1952a (%) |
| Total | 0.07 | 14 | |||
| PM | *2*2 | 0.004 | 0.00 - 0.015 | 1 (%) | 2.5186a (%) |
| *2 *4 | 0 (%) | 0.1119a (%) | |||
| *4 *4 | 0 (%) | 0.0012a (%) | |||
| Total | 0.004 | 1 | |||
| Overall Total | 1.00 | 201 | 200.9994 |
Abbreviations: PM, Poor metabolizer; IM, Intermediate metabolizer; EM, Extensive metabolizer; UM, Ultra rapid metabolizer, N/A = not applicable
a Represents no statistically significant difference between actual number and expected number by Hardy- Weinberg law in genotype distribution