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. Author manuscript; available in PMC: 2013 Sep 17.
Published in final edited form as: Curr Neurobiol. 2010 Mar;1(1):70–76.

Figure 2. Developmental PCB exposure dose-dependently increases caspase-3 activity in multiple brain regions.

Figure 2

Exposure to A1254 at 1.0 but not 0.1 mg/kg/d in the maternal diet throughout gestation and lactation increases caspase-3 activity in the cortex (A), cerebellum (B) and hippocampus (C) of rats at PND3. Comparison between brain regions of the percent increase in caspase-3 activity in a specific brain region among A1254-treated pups relative to caspase-3 activity in the same brain region among vehicle control pups indicates that developmental PCB exposure causes the greatest percentage increase in caspase activity in the cerebellum (D). Data presented as the mean ± SEM (N = 10-15 per treatment group); *p<0.05; **p<0.01 (One-way ANOVA with Newman-Keuls post hoc).