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. Author manuscript; available in PMC: 2013 Sep 17.
Published in final edited form as: Curr Neurobiol. 2010 Mar;1(1):70–76.

Figure 4. Developmental PCB exposure increases levels of oxidative stress biomarkers in the cerebellum.

Figure 4

Representative western blots (A,B) and corresponding densitometric analyses (C,D) of 4-hydroxynonenal (4-HNE, A,C) and 3-nitrotyrosine (3-NT, B,D) in homogenates of whole cerebellum from PND3 rats. Exposure to A1254 at 1.0 but not 0.1 mg/kg/d in the maternal diet throughout gestation and lactation increases 4-HNE, a biomarker of oxidized lipids and 3-NT, a biomarker of oxidized proteins, with the former effect reaching statistical significance. Data presented as the mean ± SEM (N = 4 per treatment group); ***p<0.001 (One-way ANOVA with Newman-Keuls post hoc).