Table 2.
BLP-induced maturation and activation of mouse and human DCs.
| BLP |
LPSm or TNFαh |
|||||||
|---|---|---|---|---|---|---|---|---|
| Neonatal |
Adult |
Neonatal |
Adult |
|||||
| Mouse | Human | Mouse | Human | Mouse | Human | Mouse | Human | |
| BLPs INDUCE MATURATION AND ACTIVATION OF MOUSE AND HUMAN DCs | ||||||||
| Markers (fold increase relative to non-stimulated control) | ||||||||
| CD40m or CD83h | 1.0 | 2.2 | 1.3 | 3.6 | 1.0 | 2.9 | 1.3 | 3.0 |
| CD80 | 1.2 | 2.2 | 1.1 | 2.5 | 1.4 | 2.7 | 1.8 | 1.8 |
| CD86 | 4.0 | 5.1 | 7.2 | 6.9 | 4.2 | 4.8 | 6.1 | 5.1 |
| I-Adm or HLA-DRh | 1.1 | 1.4 | 8.9 | 3.1 | 0.9 | 1.4 | 7.2 | 3.2 |
| Cytokines (fold increase relative to non-stimulated control) | ||||||||
| IL-12p70 | 1.7 | 2.3 | 1.7 | 1.6 | 2.1 | 1.5 | 1.6 | 2.0 |
| TNFα | 140.1 | 163.0 | 9.4 | 541.8 | 93.4 | 24.4 | 10.8 | 1119.7 |
| IL-10 | 3.6 | 4.1 | 11.4 | 47.6 | 3.6 | 16.3 | 20.3 | 2.1 |
| IL6 | 565.5 | 164.7 | 421.3 | 329.1 | 707.9 | 1108.3 | 428.6 | 1.6 |
| IFNγm or IL-1βh | 1.5 | 1.7 | 3.7 | 3.1 | 1.9 | 2.3 | 7.3 | 2.0 |
| MCP1m or IL8h | 1.4 | 58.9 | 1.7 | 13.4 | 2.9 | 125.5 | 1.7 | 2.6 |
Maturation and activation of neonatal and adult DCs were evaluated by measuring the upregulation of surface markers and production of specific cytokines. m, mouse; h, human.