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. 2013 Sep 17;4:280. doi: 10.3389/fimmu.2013.00280

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Copyright © 2013 Pastorelli, De Salvo, Mercado, Vecchi and Pizarro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Murine loci and genes associated with gut inflammation that are potentially related to intestinal epithelial barrier dysfunction. Colitis susceptibility loci, Cdcs, and Dssc, are identified by red bold font. Genes potentially involved in the epithelial barrier defect characteristic of SAMP mice are italicized. Genes deleted in mouse models of intestinal inflammation that affect epithelial function are underscored. The potential role of each gene in the pathogenesis of epithelial dysfunction associated with chronic intestinal inflammation is discussed within the text. Cdcs, cytokine deficiency-induced colitis susceptibility; Dssc, DSS colitis locus.