Table 4.

Water-exchange rates of Eu^III-containing DOTA-tetraamide complexes 40 and 66–80 discussed in Section 2.4.

Complex	kex (×106 s−1)	Side chain	Method	Reference
40	0.007	CH2CO2t-Bu	NMR spectroscopyc	[63]
66	0.01	H	NMR spectroscopyc	[63]
66	0.0083a	H	1H-NMR spectroscopy	[65]
67	0.005	CH2Ph	NMR spectroscopyc	[63]
68	0.004	CH(CH3)Ph	NMR spectroscopyc	[63]
69	0.003	CH2CO2CH2CH3	NMR spectroscopyc	[63]
69	0.0013a	CH2CO2CH2CH3	1H-NMR spectroscopy	[27]
70	0.002	CH2CO2nBu	NMR spectroscopyc	[63]
71	0.002	CH2CO2CH2Ph	NMR spectroscopyc	[63]
72	>1 a	4-heptyl	CEST	[15]
73	0.059 a	3-pentyl	CEST	[15]
74	0.10 a	t-Bu	CEST	[15]
75	0.027 a	i-Pr	CEST	[15]
76	0.0096 a	C(CH3)2CO2−	CEST	[15]
77	0.0064 a	CH3	1H-NMR spectroscopy	[65]
78	0.00077 a	CH2PO(OCH2CH3)2	1H-NMR spectroscopy	[66]
79	0.0048 a	C(CH3)2CO2CH2CH3	CEST	[15]
80	0.015 b	CH2PO32−	1H-NMR spectroscopy	[27]

^a for the square-antiprism (SAP) isomer in CH₃CN, ^b in water, ^c the authors did not specify ¹H or ¹⁷O.