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. Author manuscript; available in PMC: 2013 Sep 17.
Published in final edited form as: Adv Exp Med Biol. 2013;762:155–181. doi: 10.1007/978-1-4614-4433-6_6

Fig. 6.1.

Fig. 6.1

moDC–SIV interactions and possible modes of virus transmission to permissive CD4+ T cells. SIV internalized via CLRs (and other possible attachment receptors) is held in the periphery of immature moDCs vs. a deeper perinuclear location in mature moDCs. Captured virus rapidly moves to the contact points between the DC and CD4+ T cells and is transferred to the T cells, which amplifies infection. Entrapped virus is degraded in lysosomes within 24 h, ultimately reducing the infectious virus load in the DCs. R5 HIV infection of immature DCs and subsequent spread of newly produced viruses to T cells have also been demonstrated for human moDCs, but this has not been extensively studied with macaque moDCs