Table 6.1.

Characteristics of NHP mDCs and pDCs

DC subsets	Co-stimulatory molecules	TLR expression	Functions	SIV-induced maturation
mDCs	CD40mo	TLR3	Endocytic	No changes in CD80 and CD86 expression
	CD80low	TLR4	Produce IL-12
	CD86mo	TLR7	Stimulate T cells (most potently when mature)
		TLR8
pDCs	CD40mo	TLR7	Endocytic	Increased CD80 and CD86 expression
	CD80low	TLR9	High producers of IFN-α
	CD86low		Produce TNF-α	IFN-α release

Summarized from (Coates et al. 2003; Teleshova et al. 2004b; Ketloy et al. 2008; Brown et al. 2009; Gujer et al. 2011)