Table 6.1.
DC subsets | Co-stimulatory molecules | TLR expression | Functions | SIV-induced maturation |
---|---|---|---|---|
mDCs | CD40mo | TLR3 | Endocytic | No changes in CD80 and CD86 expression |
CD80low | TLR4 | Produce IL-12 | ||
CD86mo | TLR7 | Stimulate T cells (most potently when mature) | ||
TLR8 | ||||
pDCs | CD40mo | TLR7 | Endocytic | Increased CD80 and CD86 expression |
CD80low | TLR9 | High producers of IFN-α | ||
CD86low | Produce TNF-α | IFN-α release |
Summarized from (Coates et al. 2003; Teleshova et al. 2004b; Ketloy et al. 2008; Brown et al. 2009; Gujer et al. 2011)