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Schematics showing the photoactivation-dependent CreER/loxP system in the Rosa26CreERT2;mT/mG reporter mice. To produce a light-sensitive CreER/loxP system, 4-OHC was modified with a light sensitive caging group to inhibit its ability to induce CreER-mediated recombination. Photoactivated release of 4-OHC induces EGFP gene expression in illuminated cells.
