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. Author manuscript; available in PMC: 2013 Sep 17.
Published in final edited form as: Drug Discov Today Dis Models. 2011 Oct 19;9(1):e33–e38. doi: 10.1016/j.ddmod.2011.09.001

Table. Comparison Summary Table.

Comparison Summary Table of Models Used to Study Sepsis-Induced Immunosuppression

In vivo model 1: Cecal Ligation and Puncture In vivo model 2: Colon Ascendens Stent Peritonitis In vitro model In silico model
Pros

  • Mimics abdominalpolymicrobial sepsis

  • Reproduces the inflammatory phase of sepsis and the resultant sepsis-induced immunosuppression

 Mimics ongoing sepsis from polymicrobial diffuse peritonitis. Allows study at cell-specific and molecular level No laboratory equipment, animals or biological samples needed
Cons Not able to replicate other causes of sepsis May not simulate the immunosuppression of sepsis, given the ongoing inflammatory stimulus Unable to integrate the immune system's response as a whole Depends on previously discovered pathways and responses
Best use of model Study of pathogenetic mechanisms and preclinical treatment trials Study of the inflammatory phase of sepsis and possible treatment trials Study of molecular and cell-specific pathways Helps to streamline animal studies
References [27] [42] [11] [50]