Fig. 2.

Heterogeneity of fat. (A-C) Adipose depots are positioned at stereotypic times and locations with defined sizes; shown are subcutaneous (SQ) fat depots (A), perigonadal (visceral) fat depots (B) and intrascapular brown adipose tissue (C) from three unrelated mice. Histologically, white adipose depots differ in adipocyte size; subcutaneous depots are more heterogeneous, containing both uni- and multilocular adipocytes and interstitial tissue, whereas visceral depots are more uniform and contain mostly unilocular adipocytes. Morphologically, brown adipose tissue is very distinct from white adipose tissue with uniformity of multilocular lipid droplets.