Table 2.
Protein change in the metastatic UM cell line.
| Category/name | Function | Change (x-fold) |
|---|---|---|
| Cellular defense | ||
| HSP27 | Protein stabilisation | ++ |
| Apoptosis/degeneration | ||
| Cathepsin Z | Lysosomal proteolysis | ++ |
| Proliferation | ||
| Annexin | Growth factor | ++ |
| Migration | ||
| Cofilin | Actin turnover | +++ |
| Tropomodulin 3 | Actin turnover | ++++++ |
| CLIM1 | Actin kinase adaptor | ++++++ |
| Galectin | Cell to cell interaction | ++ |
| β-Hexosaminidase β-subunit | Glycosidasis | ++++++ |
| Metabolism | ||
| Pyruvate kinase 3 | Glycolysis | − |
| Enolase 1 | Glycolysis | − |
| Nuclear transport | ||
| Ran-binding protein 1 | RanGAP activity | ++ |
| elF5A | Cofactor in nuclear export | ++++++ |
| Translation | ||
| CRHSP-24 | Translation regulating protein | ++++++ |
Adapted from Zuidervaart et al. [37] (+) 0–1.5. (++) 1.5–5. (+++) 5–10. (++++) 10–50. (+++++) 50–100. (++++++) >100-fold increase. Minus depicts a decrease.