Table 1. Distribution of C4A and C4B CNV Frequency^*.

	C4A/C4B Gene Copy Number Frequency (%)
Patient	0	1	2	3	4
RA	1.2/4.4	19.4/35.6	46.3/56.3	3.1/29.4	2.5/0.6
Sero(+)	1.7/6.1	18.3/37.4	40.0/53.9	35.7/1.7	2.6/1.7
Sero(−)	0/0	22.2/31.1	62.2/62.2	13.3/6.7	2.2/0
Non-RA	1.1/1.1	22.5/21.3	49.4/73.0	23.6/2.2	3.4/2.2
Healthy	0/2	17.6/19.6	66.7/70.6	15.7/5.9	0/2.0
Ohio Cohort	0/2.7	17.3/26.9	56.3/63.3	21.6/6.8	3.3/0.2

^*Frequency analysis of C4A and C4B gene copy number shown as percentage of each group. Number of individuals analyzed in each group: RA: n=160; Seropositive RA (Sero+) n =115; Seronegative RA (Sero−) n=45; Non-RA patients (non-RA) n =88; Healthy volunteers (Healthy) n=51. Ohio Cohort represents a separate, unrelated healthy control cohort [(n=517; 389 females, mean age ± SD: 38.6 ± 11.1 years old; and 128 males, 34.3±12.1 years old (22)]. All patients and volunteers are of European descent. No patient had more than 5 copies of either C4A or C4B.