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Panel A) shows the overall structure of the kappa-OR, showing the binding model of ff(D-nle)r-NH2, relevant residues are labeled. B) and C) Comparison of the orientation of Trp in the presence of the antagonist crystallographic ligand, JDTic, shown in green, and the agonist tetrapeptide ff(D-nle)r-NH2, shown in gray.
