Skip to main content
. Author manuscript; available in PMC: 2014 May 30.
Published in final edited form as: Cell Rep. 2013 May 16;3(5):1640–1650. doi: 10.1016/j.celrep.2013.04.016

Table 1.

Rescue of Senp1 Mutants by Sumo1 Heterozygosity

Senp1 Genotype
Strain Stage +/+ +/− −/− −/− Phenotype
Senp1M1 Sumo1+/− E14.5–E16.5 15 38 16 all normal
P0 9 17 9 4 stillborn
Senp1Gt Sumo1+/− E14.5–E16.5 12 22 15 5 dead/dying
P0 16 21 7 6 stillborn

The number of embryos or pups from crosses within the Senp1M1 Sumo1 or Senp1GtSumo1 strains listed by Senp1 genotype (WT, +/+; heterozygous, +/−; homozygous, −/−). All individuals were heterozygous for Sumo1 mutation. Sumo1 heterozygosity rescues 100% of Senp1M1 mutants past E14.5. The number of Senp1M1/M1 Sumo1+/− individuals found at birth also matches Mendelian expectations. Most pups nursed and survived more than 1 day. For Senp1Gt/Gt Sumo1+/−, rescue is incomplete, and the majority of rescued pups were found dead on P0.