Appendix Table 1.
Risk of Basal-Cell Carcinoma According to Cumulative Midrange UV-B Flux Exposure and Susceptibility to Sunburn as a Child/Adolescent in Age- and Multivariate-adjusted Analyses, Nurses' Health Study (1986–2006) and Health Professionals' Follow-up Study (1988–2006)
| Quintile of UV-B Flux Exposure |
Susceptibility to Sunburn as a Child/Adolescent |
P for Interactionc | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Burn or Some Redness |
Burn |
Painful or Blistering Burn |
|||||||||||
| RR1a | 95% CI | RR2b | 95% CI | RR1a | 95% CI | RR2b | 95% CI | RR1a | 95% CI | RR2b | 95% CI | ||
| Nurses' Health Study | |||||||||||||
| 1 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 0.001 |
| 2 | 1.71 | 1.46, 2.00 | 1.68 | 1.44, 1.97 | 1.57 | 1.23, 2.01 | 1.54 | 1.20, 1.97 | 1.74 | 1.35, 2.25 | 1.74 | 1.35, 2.25 | |
| 3 | 2.64 | 2.14, 3.25 | 2.58 | 2.09, 3.18 | 1.80 | 1.31, 2.48 | 1.75 | 1.27, 2.40 | 2.25 | 1.61, 3.14 | 2.26 | 1.62, 3.16 | |
| 4 | 3.53 | 2.79, 4.45 | 3.43 | 2.72, 4.32 | 2.60 | 1.82, 3.71 | 2.50 | 1.75, 3.57 | 3.01 | 2.06, 4.41 | 3.03 | 2.07, 4.43 | |
| 5 | 4.14 | 3.27, 5.25 | 3.99 | 3.15, 5.06 | 2.97 | 2.07, 4.27 | 2.83 | 1.97, 4.06 | 3.12 | 2.11, 4.62 | 3.14 | 2.12, 4.65 | |
| Ptrend | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | |||||||
| Health Professionals' Follow-Up Study | |||||||||||||
| 1 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | 0.01 |
| 2 | 1.26 | 0.92, 1.73 | 1.23 | 0.90, 1.69 | 1.41 | 1.13, 1.77 | 1.41 | 1.12, 1.76 | 1.17 | 0.89, 1.54 | 1.16 | 0.88, 1.52 | |
| 3 | 1.97 | 1.34, 2.90 | 1.89 | 1.28, 2.78 | 1.78 | 1.35, 2.34 | 1.76 | 1.33, 2.32 | 1.48 | 1.06, 2.07 | 1.45 | 1.04, 2.03 | |
| 4 | 2.34 | 1.54, 3.54 | 2.20 | 1.45, 3.34 | 1.86 | 1.38, 2.50 | 1.84 | 1.36, 2.47 | 1.81 | 1.26, 2.60 | 1.76 | 1.22, 2.52 | |
| 5 | 2.63 | 1.71, 4.06 | 2.44 | 1.58, 3.76 | 1.92 | 1.41, 2.61 | 1.88 | 1.38, 2.56 | 1.69 | 1.16, 2.48 | 1.63 | 1.11, 2.38 | |
| Ptrend | <0.0001 | 0.0002 | 0.03 | 0.04 | 0.04 | 0.07 | |||||||
Abbreviations: CI, confidence interval; RR, relative risk; UV-B, ultraviolet B.
a Adjusted for age.
b Multivariate analysis controlled for age, family history of melanoma, natural hair color, number of moles on an extremity, lifetime number of severe/blistering sunburns, and cumulative UV-B flux exposure.
c P value for interaction between susceptibility to sunburn as a child/adolescent and cumulative UV-B flux exposure.