Table I.
The predicted target genes analyzed in this study.
| Gene symbol | Gene name | Assay ID | Function | Pathway | Remarks |
|---|---|---|---|---|---|
| AHNAK | AHNAK nucleoprotein (desmoyokin) | Hs00225285_m1 | Protein-protein binding | Signal transduction | NSCLC prognostic biomarker (19,20) |
| ATRX | Alpha thalassemia/mental retardation syndrome X-linked | Hs00230877_m1 | Transcriptional regulator, chromatin remodeling | Transcription | NSCLC prognostic biomarker (19,20) |
| DLC1 | Deleted liver cancer 1 | Hs00183436_m1 | Regulation of small GTP-binding proteins | Signal transduction | Tumor suppressor gene (60) and NSCLC prognostic marker (21) |
| E2F4 | E2F transcription factor-4 | Hs00608098_m1 | Transcriptional factor, cell cycle, apoptosis | Transcription | NSCLC prognostic maker (19,20) |
| HFE | Hemochromatosis | Hs00373474_m1 | Regulation of body iron metabolism | Iron metabolism | NSCLC prognostic biomarker (21) |
| HNRNPA3 | Heterogeneous nuclear ribonucleo protein-A3 | Hs00864845_s1 | Cytoplasmic RNA binding and trafficking, protein binding | Signal transduction | NSCLC prognostic biomarker (19,20) |
| THBS1 | Thrombospondin 1 | Hs00962914_m1 | Extracellular adhesive glycoprotein | Protein interaction | NSCLC prognostic biomarker (21) |
| UBE2I | Ubiquitin-conjugating enzyme E2I | Hs00163336_m1 | Ubiquitin-activating protein | Protein degradation | NSCLC prognostic biomarker (19,20) |
| UBA6 | Ubiquitin-like modifier activating enzyme-6 | Hs00414964_m1 | Ubiquitin-conjugation for protein degradation | Protein degradation | NSCLC prognostic biomarker (21) |