Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Neurobiol Learn Mem. 2013 Jul 11;105:54–62. doi: 10.1016/j.nlm.2013.06.016

Figure 2. Cdk5f/f/CW2 animals display pronounced hyperactivity in the open field arena.

Figure 2

(A) Compared to control Cdk5f/f littermates, Cdk5f/f/CW2 exhibited greater horizontal activity as measured by infrared beam breaks across the open field arena (Cdk5f/f, 9834 ± 623.7; Cdk5f/f/CW2, 14560 ± 1421; p=0.0063).

(B) Consistent with the observation that Cdk5f/f/CW2 display increased overall activity, Cdk5f/f/CW2 animals were consistently and significantly more active overall and traveled a greater distance in the open field arena over a period of 60 min compared to Cdk5f/f control littermates (Cdk5f/f, 6067 ± 598.6; Cdk5f/f/CW2, 12100 ± 1970; p=0.0076).

(C) Compared to control Cdk5f/f littermates, Cdk5f/f/CW2 animals spent more time in the center of the open field arena, indicative of reduced anxiety that is consistent with observations from the light/dark test (Cdk5f/f, 323.2 ± 63.17; Cdk5f/f/CW2, 643.6 ± 129.3; p=0.0356).

(D) Compared to control Cdk5f/f littermates, Cdk5f/f/CW2 animals spent less time in the margin of the open field arena (Cdk5f/f, 3277 ± 63.17; Cdk5f/f/CW2, 2956 ± 129.3; p=0.0356).

(E) Compared to control Cdk5f/f littermates, Cdk5f/f/CW2 traveled a greater distance in the center of the open field, indicating reduced anxiety (Cdk5f/f, 1421 ± 253.0; Cdk5f/f/CW2, 2461 ± 419.8; p=0.0458).

(F) Compared to control Cdk5f/f littermates, Cdk5f/f/CW2 animals traveled a greater distance in the margin of the open field test, reflecting a generalized hyperactivity (Cdk5f/f, 4648 ± 417.2; Cdk5f/f/CW2, 9637 ± 1808; p=0.0123). N=9 animals for Cdk5f/f; N=8 animals for Cdk5f/f/CW2 genotypes (Cdk5f/f, 4388 ± 313.0; Cdk5f/f/CW2, 5187 ± 507.0; p=0.1893). Data shown are means ± SEM. Statistical significance was calculated using Student’s t-test (*p < 0.05; **p < 0.01; ***p < 0.001).