Table II.
The classification of differentially expressed genes according to signaling pathways in HPV16 E6E7 transfected cells compared with vector alone cells.
| KEGG pathway | Regulation
|
|
|---|---|---|
| Upregulation | Downregulation | |
| Focal adhesion | RAC1, VAV3, GSK3B, THBS3, ITGB4, LAMA3 | ITGA11, LAMB1, ITGA2, IGF1R, THBS2, PDGFC, CRKL, COL1A1, TNC, CAV2, BIRC2, PRKCA, COL3A1, COL6A2, COL1A2, PDGFRB, MAPK1 |
| Cytokine-cytokine receptor interaction | CCL26, CXCL16, TNFSF9, CD70, TNFSF10, KITLG, IL28RA | IL4R, IL8, TNFRSF11B, PDGFC, IL6, IL1RAP, IL7R, TNFRSF19, IL1B, CXCL1, IL11, TGFB2, TNFRSF9, PDGFRB |
| MAPK signaling pathway | RAC1, MKNK2, IKBKG, CD14, BDNF, HSPA2, CDC25B | CRKL, NGF, PPM1B, PRKCA, IL1B, PPP3CB, EVI1, TGFB2, PDGFRB, MAPK1 |
| ECM-receptor interaction | THBS3, ITGB4, LAMA3 | ITGA11, LAMB1, ITGA2, THBS2, COL1A1, TNC, COL3A1, COL6A2, COL1A2, CD47 |
| Regulation of actin cytoskeleton | RAC1, VAV3, BAIAP2, CD14, ITGB4 | ITGA11, ITGB2, ITGA2, PDGFC, CRKL, DIAPH3, PDGFRB, MAPK1 |
| Jak-STAT signaling pathway | STAT1, IRF7, STAT4, SOCS2, IL28RA, IFI30, IFI35, IFI44L, IFIH1, IFIT1, IFIT2, IFIT3, IFITM1, IKBKG | IL4R, JAK2, IL7R, IL6, IL11, SPRY2 |
| Cell cycle | GSK3B, CDC25B | CDKN2C, CHEK1, CDC45L, CDC2, CDKN1B, MAD2L1, TGFB2, CCNE2 |
| p53 signaling pathway | CHEK1, CDC2, SERPINE1, STEAP3, CCNE2 | |