Table 1.

Pharmacogenetic studies of antidepressant treatment response conducted in Sequenced Treatment Alternatives to Relieve Depression (STAR^*D)

Study and gene	Marker	p	Sample N	Phenotype definitiona	Observations
Teranishi et al. (40)			1,804	UCSF
PDE1A	rs1549870	ns
PDE11A	rs1880916	ns
Kraft et al. (45)			1,308	UCSF	White subset reported
SLC6A4	rs1042173	ns
	rs140701	ns
	rs140700	.03
	rs6354	ns
	rs2066713	ns
	rs16965628	ns
	rs2020934	ns
	rs2020933	ns
	rs25533	ns
	5-HTTLPR	ns
	rs25531	ns
Hu et al. (36)			1,655	NIMH	Association with adverse effect burden
SLC6A4	5-HTTLPR	ns
Leckman et al. (38)			1,809	NIMH
FKBP5	rs1360780	ns
	rs4713916	.04
	rs3800373	ns
Paddock et al. (35)			1,816	NIMH
GRIK4	rs1954787	<.001
Peters et al. (63)			1,953	UCSF & NIMH
HTR2A	rs1923884	.02
Peters et al. (63) and			1,953 and	UCSF & NIMH
McMahon et al. (32)			1,329
HTR2A	rs7997012	<.001
McMahon et al. (32)		<.001	1,372	UCSF & NIMH
HTR2A	rs6313	ns
	rs6311	ns
Domschke et al. (41)			1,953	NIMH	rs6265 (val66met)
BDNF	rs1519479	ns
	rs2203877	ns
	rs1519480	ns
	rs6265	ns
	rs11030104	ns
	rs12273363	ns
	rs7931247	ns
	rs1491850	ns
	rs7119334	ns
	rs10742184	ns
Peters et al. (42)			1,877	UCSF
ABCB1	rs1045642	ns
CYP2D6		ns
CYP2C19		ns
CYP3A4		ns
CYP3A5		ns

^aUCSF, University of California, San Francisco; NIMH, National Institute of Mental Health