Table 3.
Pharmacogenetic studies of adverse events conducted in Sequenced Treatment Alternatives to Relieve Depression (STAR*D)
| Study, adverse event, and gene | Marker | p | Sample N | Observations |
|---|---|---|---|---|
| Perlis et al. (34) | 1,473 | |||
| Decreased libido | ||||
| GRIA3 | rs2285127 | <.001 | ||
| rs2269551 | .004 | |||
| rs550640 | .047 | |||
| GRIK2 | rs513216 | .002 | ||
| rs9404130 | .012 | |||
| rs2518302 | .031 | |||
| rs2518224 | .038 | |||
| Difficulty achieving orgasm | ||||
| GRIA1 | rs10515697 | .004 | ||
| rs1994862 | .004 | |||
| rs1864205 | .018 | |||
| Difficulty achieving erection | ||||
| GRIN3A | rs2050641 | .002 | ||
| rs1323423 | .003 | |||
| rs1323427 | .004 | |||
| rs2050639 | .012 | |||
| rs1983812 | .019 | |||
| rs1004362 | .026 | |||
| rs2417290 | .035 | |||
| Laje et al. (8) | 1,915 | Genotypic test | ||
| Treatment-emergent suicidal ideation | ||||
| GRIK2 | rs2518225 | <.001 | ||
| GRIA3 | rs4825476 | <.001 | ||
| Laje et al. (67) | 274 | Genomewide association study in subsample | ||
| Treatment-emergent suicidal ideation | ||||
| PAPLN | rs11628713 | <.001 | ||
| IL28RA | rs10903034 | <.001 | ||
| Perlis et al. (65) | 1,447 | Male subjects only. Haplotypes CAATC (p=.004) and CAGTT (p=.009) were also associated in males | ||
| Treatment-emergent suicidal ideation | ||||
| CREB1 | rs2709376 | ns | ||
| rs2253206 | ns | |||
| rs7569963 | .005 | |||
| rs7594560 | ns | |||
| rs4675690 | .005 |