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. Author manuscript; available in PMC: 2013 Sep 17.
Published in final edited form as: J Hum Hypertens. 2011 Jan 20;26(2):133–140. doi: 10.1038/jhh.2010.131

Summary Table

What is known about this topic:

  • Identifying predictors of left ventricular hypertrophy (LVH) has been an active area of study because of the association of LVH with cardiovascular disease morbidity and mortality.

  • Some studies have looked at candidate genes associated with blood pressure to find genetic associations with LVH, with angiotensin-converting enzyme insertion/deletion (ACE) I/D and angiotensinogen (AGT) among the most commonly researched.

What this study adds:

  • Using data from the HyperGEN study, a suggestive epistatic (gene-gene interaction) effect on LVM was observed between the ACE I/D and AGT -20A-C genetic variants among white, but not African American hypertensive participants.

  • This suggestive evidence of epistasis in the development of LVM indicates the complexity of genetic contributions to cardiac structure.