Table 1.
Summary of pH Effects on TRP Channels
| Channel type | pH effect | Side | Site of action | References |
|---|---|---|---|---|
| TRPV1 | Potentiation (gating) | Extracellular | Pore turret (E600), pre-S6 loop (E648), others | (74) |
| Inhibition (permeation) | Extracellular | Selectivity filter | (6, 207) | |
| TRPV5 | Inhibition (permeation, gating) | Extracellular | Pore turret (E522) | (224) |
| Inhibition (permeation, gating) | Intracellular | Proximal C-terminal (K607) | (223) | |
| TRPM2 | Inhibition (permeation) | Extracellular | Pore turret (H958, R960), pre-S6 loop (E994) | (34) |
| Inhibition (gating) | Intracellular | S4-S5 linker (R933) | (34) | |
| TRPM5 | Inhibition (permeation, gating) | Extracellular | S3-S4 linker (E830), pore turret (H896), pre-S6 loop (H934) | (93) |
| TRPM7 | Potentiation (permeation) | Extracellular | Selectivity filter (E1047, E1052, D1054, E1059) | (70, 88, 121) |
| TRPM6 | Potentiation (permeation) | Extracellular | Selectivity filter (E1024, E1029) | (88) |
| TRPC4 | Potentiation | Extracellular | Unknown | (157) |
| TRPC5 | Potentiation (gating), inhibition (permeation) | Extracellular | Pore turret (E543), pre-S6 loop (E595) | (79, 157) |
| TRPC6 | Inhibition | Extracellular | Unknown | (157) |
| TRPML1 | Potentiation | Luminal (lysosome) | Unknown | (32) |
| TRPML2 | Potentiation | Luminal (lysosome) | Unknown | (32) |
| TRPP3/PKD1L3 | Potentiation (gating, permeation?) | Extracellular | Unknown | (66) |
| TRPA1 | Potentiation (gating) | Extracellular | Unknown | (179) |