. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: J Allergy Clin Immunol. 2013 Jul 30;132(3):536–544. doi: 10.1016/j.jaci.2013.07.006

Table I. Major NK cell receptors with reported ligands in mouse and man.

Receptor	Species		Reported Ligand(s)^*
	Human	Mouse
Inhibitory Receptors
KIR2DL1 (CD158a)	×		Group 2 HLA-C
KIR2DL2, KIR2DL3 (CD158b1, -b2)	×		Group 1 HLA-C, some Group 2 HLA-C and some HLA-B
KIR3DL1 (CD158e1)	×		HLA-Bw4
Ly49A (Klra1)		×	H2-D^d, -D^k, -L^d, -D^b, -K^b, -D^p, -M3
Ly49C (Klra3)		×	H2-D^b, -K^b, -D^d, -K^d, -D^k
Ly49E (Klra5)		×	Urokinase plasminogen
Ly49G (Klra7)		×	H2-D^d, -K^d, -L^d, -D^b, -D^k, -D^r
Ly49I (Klra9)		×	H2-K^b, -K^d, -D^k, -K^k, m157 (mouse cytomegalovirus)
NKG2A (CD159A)/CD94	×	×	HLA-E (human), Qa-1^b (mouse)
LILRB1 (ILT2, LIR1, CD85j)	×		HLA-A, -B, -C, -E, -G, -F, UL18 protein (human cytomegalovirus)
KLRG1	×	×	E-, N-, and R-cadherin
NKR-P1A (CD161)	×		LLT1
NKR-P1B, NKR-P1D		×	Ocil/Clr-b
Activating Receptors
NKp46 (NCR1; CD335)	×	×	Human: HSPG, heparin, VM, HA (IV, VV, ECTV), HN (SeV, NDV), PfEMP-1(P. falciparum), F. nucleatum; Mouse: influenza-infected cells, F. nucleatum
NKp30 (NCR3; CD337)	×		B7-H6, BAT3, HSPG, HA (VV, ECTV), pp65 (HCMV), PfEMP-1 (P. falciparum)
FcγRIIIA (CD16)	×	×	Fc of human IgG immune complexes
NKG2D (CD314)	×	×	Human: MICA/B, ULBP1, -2, -3, -4, -5, -6 Mouse: RAE-1a, -1b, -1d, -1e, -1g, H60a, H60b, H60c, MUTL1
KIR2DS1 (CD158h)	×		HLA-C2
KIR2DS4 (CD158i)	×		Some HLA-C1 and –C2, HLA-A11
KIR2DL4 (CD158d)	×		HLA-G
NKp65 (KLRF2)	×		KACL (keratinocyte-associated C-type lectin)
NKp80 (KLRF1)	×		AICL (activation-induced C-type lectin)
DNAM-1 (CD226)	×	×	Nectin-2, PVR
NKG2C (CD159C)/CD94, NKG2E/CD94	×	×	HLA-E (human), Qa-1^b (mouse)
Ly49D (Klra4)		×	H2-D^d, -D^r, D^sp2
Ly49H (Klra8)		×	m157 (mouse cytomegalovirus)
Ly49P (Klra16)		×	H2-D^d, -D^k, m04 (mouse cytomegalovirus)
NKR-P1F		×	Clr-c, -d/x, -g
NKR-P1G		×	Clr-dx, -g, -f
Activating/Inhibitory Receptors
2B4 (CD244)	×	×	CD48
NKp44 (NCR2; CD336)	×		PCNA, HS, heparin, E-protein (DV, WNV), HA (IV, SeV), HN (NDV), Mycobacterium, N. farcinica, P. aeruginosa

Abbreviations used: HSPG: heparan sulfate proteoglycan, VM: vimentin, HA: haemagglutinin, HN: haemagglutinin–neuraminidase, IV: influenza virus, VV: vaccinia virus, ECTV: ectromelia virus, SeV: Sendai virus, NDV: Newcastle disease virus, P. falciparum: Plasmodium falciparum, F. nucleatum: Fusobacterium nucleatum, N. farcinica: Nocardia farcinica, P. aeruginosa: Pseudomonas aeruginosa.