Skip to main content
. Author manuscript; available in PMC: 2013 Sep 17.
Published in final edited form as: Chem Biol. 2012 Sep 21;19(9):1187–1198. doi: 10.1016/j.chembiol.2012.07.021

Figure 6. PKM2 Activation Coupled with Serine Deprivation Induces Cell Cytostasis.

Figure 6

Model showing the cytostatic effect achieved by PKM2 activation and serine deprivation. Cpd 9 treatment results in reduced flow through the endogenous serine biosynthetic pathway and increased levels of serine transporters (bottom left). Serine deprivation results in increased flow through the serine biosynthetic pathway (top right). Simultaneous PKM2 activation and serine deprivation results in a block in cell proliferation (bottom right).