Table 1. Relationship between VEZT expression levels in cancer tissues and clinicopathological factors in patients with gastric cancer.
| Factors | No. of patients | Mean expression of VEZT（mean±SD) | P-value |
|---|---|---|---|
| Gender | |||
| Male | 57 | 14.87±2.03 | 1.382 |
| Female | 47 | 15.47±3.15 | |
| Age(year) | |||
| <65 | 49 | 18.62±2.15 | 0.584 |
| ≥65 | 55 | 13.11±3.45 | |
| Tumor size | |||
| <5cm | 51 | 17.16±3.05 | 2.682 |
| ≥5cm | 53 | 11.26±3.52 | |
| Cell differentiation | |||
| Poor differentiation | 68 | 18.21±1.65 | 1.827 |
| Moderate differentiation | 36 | 16.6±2.46 | |
| Gross appearance | |||
| Borrmann Ⅰ+Ⅱtype | 32 | 17.25±3.46 | 2.361 |
| Borrmann Ⅲ+Ⅳtype | 72 | 15.21±6.58 | |
| Site of tumor | |||
| Cardia | 21 | 19.34±2.53 | 0.692 |
| Body | 36 | 11.24±2.61 | |
| Antrum | 47 | 17.35±2.87 | |
| Lymphatic metastasis | |||
| Positive | 74 | 7.42±7.25 | 0.027* |
| Negative | 30 | 18.26±9.32 | |
| Depth of cancer invasion | |||
| T2 | 25 | 18.35±7.82 | 0.041* |
| T3 | 63 | 22.12±4.21 | |
| T4 | 16 | 24.78±5.41 | |
| Distal metastasis | |||
| Positive | 24 | 9.34±6.09 | 1.032 |
| Negative | 80 | 12.35±8.62 | |
| TNM# Stage | |||
| Ⅰ | 15 | 6.35±7.16 | 0.0385* |
| Ⅱ | 28 | 16.37±4.56 | |
| Ⅲ | 48 | 17.24±1.41 | |
| Ⅳ | 13 | 7.41±2.36 |
We analyzed the relationship between VEZT expression levels in cancer tissues and clinicopathological factors in gastric cancer samples versus adjacent normal tissue (n = 104). We found that the expression level of VEZT was significantly associated with lymphatic metastasis, depth of cancer invasion and TNM stage (Table 1, P < 0.05). However, VEZT expression levels were not associated with gender, age, tumor size, cell differentiation, gross appearance, site of tumor and distant metastasis.
#: TNM, tumor-node-metastasis; *p < 0.05.