Table 2. Multivariate Analysis of Risk Factors Associated with the Presence of Carotid Plaques in 429 Italian Patients with Non-alcoholic Fatty Liver Disease.

Sicilian NAFLD Cohort			Northern Italian NAFLD Cohort
(n = 162)			(n = 267)
	Multivariate Analysis			Multivariate Analysis
Variable	OR (95% CI)	p value	Variable	OR (95% CI)	p value
Age ≥50 years	5.39 (2.14–13.5)	<0.001	Age >50 years	7.91(3.72–18.3)	<0.001
Femal Gender	2.10 (0.91–4.87)	0.08	BMI Kg/m2	1.00(0.97–1.05)	0.95
Arterial Hypertension	0.86 (0.34–2.13)	0.75	Arterial Hypertension	2.08(1.11–3.89)	0.02
Type 2 Diabetes	5.29 (1.51–18.5)	0.009	ALT– IU/Ml	1.00(0.99–1.01)	0.86
Alanine Aminotransferase – IU/L	0.99 (0.98–1.00)	0.08	LDL mg/dl	0.99(0.99–1.01)	0.88
LDL Cholesterol – mg/dL	1.00 (0.99–1.01)	0.17	Ferritin log ng/ml	1.96(1.41–2.83)	<0.001
Blood Glucose – mg/dL	0.99 (0.97–1.00)	0.39	PNPLA3 GG genotype	1.15(0.42–3.34)	0.49
PNPLA3 GG genotype	2.94 (1.12–7.70)	0.02
Lobular inflammation grade 2–3	1.43 (0.59–3.49)	0.42
Severe Liver Fibrosis	1.09 (0.41–2.91)	0.85

Abbreviation: IU, international units; BMI, body mass index; LDL, low density lipoprotein; ALT, alanine aminotransferase; PNPLA3: patatin-like phospholipase-3.