Table 2. Multivariate Analysis of Risk Factors Associated with the Presence of Carotid Plaques in 429 Italian Patients with Non-alcoholic Fatty Liver Disease.
Sicilian NAFLD Cohort | Northern Italian NAFLD Cohort | ||||
(n = 162) | (n = 267) | ||||
Multivariate Analysis | Multivariate Analysis | ||||
Variable | OR (95% CI) | p value | Variable | OR (95% CI) | p value |
Age ≥50 years | 5.39 (2.14–13.5) | <0.001 | Age >50 years | 7.91(3.72–18.3) | <0.001 |
Femal Gender | 2.10 (0.91–4.87) | 0.08 | BMI Kg/m2 | 1.00(0.97–1.05) | 0.95 |
Arterial Hypertension | 0.86 (0.34–2.13) | 0.75 | Arterial Hypertension | 2.08(1.11–3.89) | 0.02 |
Type 2 Diabetes | 5.29 (1.51–18.5) | 0.009 | ALT– IU/Ml | 1.00(0.99–1.01) | 0.86 |
Alanine Aminotransferase – IU/L | 0.99 (0.98–1.00) | 0.08 | LDL mg/dl | 0.99(0.99–1.01) | 0.88 |
LDL Cholesterol – mg/dL | 1.00 (0.99–1.01) | 0.17 | Ferritin log ng/ml | 1.96(1.41–2.83) | <0.001 |
Blood Glucose – mg/dL | 0.99 (0.97–1.00) | 0.39 | PNPLA3 GG genotype | 1.15(0.42–3.34) | 0.49 |
PNPLA3 GG genotype | 2.94 (1.12–7.70) | 0.02 | |||
Lobular inflammation grade 2–3 | 1.43 (0.59–3.49) | 0.42 | |||
Severe Liver Fibrosis | 1.09 (0.41–2.91) | 0.85 |
Abbreviation: IU, international units; BMI, body mass index; LDL, low density lipoprotein; ALT, alanine aminotransferase; PNPLA3: patatin-like phospholipase-3.