Table 5. Association of the (C > T) rs2246833 polymorphism with coronary risk factors.
RAF Controls | RAF Premature CAD | MODEL | OR (95% CI) | P | |
---|---|---|---|---|---|
Hypo-α-lipoproteinemia | (n = 339) | (n = 572) | Recessive | 2.51 (1.25-5.04) | 0.0079 |
0.492 | 0.548 | ||||
Additive | 2.01 (1.31-3.10) | 0.0011 | |||
Hypercholesterolemia | (n = 245) | (n = 198) | |||
0.481 | 0.588 | Additive | 1.91 (1.10-3.34) | 0.0200 | |
Hypertriglyceridemia | (n = 306) | (n = 528) | Recessive | 2.02 (1.08-3.79) | 0.0230 |
0.503 | 0.574 | ||||
Additive | 1.92 (1.30-2.83) | 0.0008 | |||
Metabolic Syndrome | (n = 277) | (n = 428) | |||
0.503 | 0.554 | Additive | 1.71 (1.19-2.45) | 0.0033 | |
Type 2 Diabetes Mellitus | (n = 68) | (n = 325) | Recessive | 2.08 (1.03-4.18) | 0.0330 |
0.455 | 0.578 | ||||
Additive | 1.79 (1.17-2.74) | 0.0062 |
All association were tested using logistic regression adjusted for age, gender, BMI, and medication when appropriate. (n) Represents the number of cases with each trait.
RAF: risk allele frequency.