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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Brain Behav Immun. 2013 Jun 11;33:102–111. doi: 10.1016/j.bbi.2013.06.001

Figure 2. TNFα Reduced the Threshold for current injection to elicit Action-Potentials in CeA.

Figure 2

Shown in the upper of figures, are (A) potential traces recorded under control conditions and (B) traces obtained from the same neuron after a 5-min treatment with 60-ng/ml TNFα. The injected current was increased by 100 pA with each presentation and traces for the highest subthreshold current and the threshold current are shown. Threshold current was 600 pA in (A) and 400pA in (B). (C) TNFα 60-ng/ml lowered the current required to trigger an action potential [t (6)=3.59, n=7, p<0.05]. (D) When TNFα (60-ng/ml) was applied in the presence of 10 μM CNQX and 50 μM AP-5, the current threshold for eliciting an action potential did not change [t(5)=0.93; n=6, p>0.05].